I normally use eq on electric guitar tracks first, to get rid of problems, then to make them fit into a mix. The tone of a guitar track by itself without eq may sound great but wont fit the mix without frequency build up, usually mud or stridency. Compression is used on rare occasions to catch unruly dynamics, but mostly only to place a guitar in the mix at a certain depth. If you are compressing the snot out of a guitar you can certainly mess up the tone, so compress only for specific reasons and specific amounts.
So i would disable eq and compression and find what you dont like about a track sonics first. Personally i find somewhere around 1.3 k needs a little cutting and depending on the part, a little cut somewhere in the 5k range. Sometimes i will pull a tiny bit down in the boxy range, ~350-450 ish but if you pull this down more than about a db you can lose the sound of the guitar. Your specific areas may vary. I like to take an eq cut of 2-3 db with a q slightly less than 1(semi narrow) and slowly sweep from about 6 k down to 700-800 hz, and usually there is one or two points where suddenly the guitar just pops. Narrow the q to find the center frequency(ies), then widen the q to sound natural. Bring cut back to zero and slowly cut to taste. Dont compress anything until you get your tone right.