I'm not sure how the new version works,but the old versions did'nt play nice with Cakewalk.
Hardcore Giga users usually have a seperate machine just to run it on.
Gigastudio sounds great,but most other samplers have closed the gap.I have Kompakt,which is the little brother to Kontakt and I'm very happy with it.
The first thing you need to figure out is if your computer can handle a decent sampler,and if the sampler is compatible to your host program,be it a VSTi or DXi,or whatever.
In the end it's mostly the sample you use rather than the program you use in in.