I suppose it is remotely possible that your headphones are bad, but I would be surprised. To find out for sure, when you hear a glitch, try backing up a few seconds and play it again at a lower volume. If you hear the same glitch, then the pop is part of the recording. If you don't, then the problem is occurring during playback (and might be the headphones, but I still would be surprised).
The problem is definitely not your mic. It can't be the mic if you get the same symptoms when using a cable to a keyboard. I'm about 99% sure that the problem is a compatibility problem between the interface and your computer.
To fix the problem, try the following in order until something works:
1. Try hooking your audio interface up to a different USB port.
2. Try turning off wireless networking while you record.
3. Try unplugging all other USB devices to see if they are causing the problem. Oh, and do not even think about recording to a USB hard drive.

4. Go into BIOS (usually you hold down a key immediately after turning the machine on) and disable every port that you don't use regularly.
5. Read this:
http://www.helpwithpcs.com/upgrading/change-irq-settings.htm
and follow the steps described to adjust your computer's configuration so that your USB controller does not share an IRQ with anything.
6. If it won't let you change IRQ settings, see if it is possible to change the IRQ mapping in BIOS.
7. If not, read this:
http://support.microsoft.com/kb/299340/en-us
and reinstall Windows with ACPI disabled, then repeat step 5. Note that this solution is something of a last resort and may decrease how long you can run your laptop on battery.
Did I leave anything out?
