I still think that the solution is to ditch _all_ of those small (>50mm) fans, and use larger fans (60mm and up) that are run at 5-7V instead of the full 12V. The problem is the blade tip speed- the smaller fans have to move their blades that much faster, and that causes the tip vortex noise to move up in frequency- making it *much* more objectionable.
I'd be tempted to pull all the small fans from your new drive carrier, and engineer up a ventilation system with a single, large, slow fan, and some ducting to put the air where you need it. I've never seen the insides of a D160, or I'd sketch up some ideas- I'm sure that it is just different enough from the D1624 to make anything I'd draw up be useless...
If you can exhaust the hot air out the top, put the fan there, and add some intake holes on the bottom. You really want your coolest air to flow across the power supply and the drive- the main board doesn't dissipate that much heat, although it shouldn't be ignored, either. Putting the fan directly above the drive to exhaust into the rack has been the best setup for me, because the unit is directly below all my patchbays in my setup- so I have nothing but space to exhaust into. You could also put some Auralex into the inside of the rack to kill some more of the HF noise bouncing around in there, come to think of it...
Iso boxes are _really_ hard to do well enough to make them worthwhile. But you have to do what you have to do... next time around, I'll build a separate isolated, air conditioned machine room so that all the fans can scream at each other without pissing me off!