RME 96/52 is the original version which does not let you use Totalmix. The HDSP 9652 is the newer one that does let you use Totalmix. I will never give up my RME cards because The Digicheck Totalyser is the best software Toolbox (RTA, RMS and Peak levels, Phase meter and stero graph that I have ever used. There are some other cool software toolboxes, but none that seem to set up as simply and usefully as the RME, and that don't seem to tax anything on your CPU cycles. Plus, the RME stuff is not very sensitive to different hardware configs, has excellent drivers, and is built well