If u get the M Audio hardware u can use it with any software. It does allow u 2 use pro tools m audio as well. I Have some clients that come 2 my studio with nuendo sessions and I use my digidesign 002 with nuendo. I would use pro tools over cubase but that is a personal preference as I have been working in pro studio for years now. The advantage 2 having pro tools is that if u ever want 2 get something mixed for u, u can easily take it 2 a studio whereas with cubase it will be hard 2 do that.