It's probably something stupid.
Like the handle, metal corners, or if it's got a metal grille take that thing off and use it for grating soil or something - make french fries. Metal speaker grilles work for protection during transportation but they sound absolutely horrible - and you see them on JBL's and all kinds of good speaker boxes - I don't get it. You need something like burlap (non-plastic) for a grille cloth, but I agree there's not much protection there.
I've made amp cabinets in the last few years, and every amp I've redone is quieter than it originally was. The biggest culprit I found, and I think this is a chronic guitar amp problem, is that they don't mount the transformer so it doesn't physically vibrate and cause noise.
I've taken the transformers and mounted them in rubber and foam so that they simply don't act like vibrators.