Recording at a higher sample rate typically will make a difference. However, how much of a difference it makes is first, subjective, and secondly depends on many other factors including the rest of your recording chain. You personally may or may not notice much of a difference. Recording at higher sampling rates will however take up more hard drive space and tax your CPU harder. If you do change sample rates, it is important that ALL of your digital gear be setup at the same rate. I am not all too familiar with the Maudio 2496 so I don't know how it integrates with Nuendo. You may have to manually change the rate in Nuendo depending on how its all set up. On a side note, since your Maudio card is called the 24....96, I would bet that the highest rate your card is capable of utilizing is 24 bit 96khz, as opposed to 192khz. (6 khz should be plenty of resolution. I do my projects at 24bit 44.1khz. Partly do to the fact that most of my mixes involve between 24 and 48 analog tracks. My tower is very beefy, but I am not sure it would handle all that at 96khz.
