Insufficient data, dude. First, 1/4" cables come in 2 types, TS (tip-sleeve) and TRS (Tip-Ring-Sleeve). 1/4" and XLR outputs can be balanced or unbalanced (yes, some boxes have unbalanced XLR's). What matters is not whether the connections are made by XLR or 1/4", but whether they are balanced or unbalanced. It only becomes important with long runs of cable, like 30 feet or more. If you plug a 1/4" TS cable into a balanced 1/4" output, there is a slight loss of gain, about 6db, which in the greater scheme of things, is negligible. I don't know whether your friend is clueless, because from your post, I'm not sure you understood what he said. For most studio applications, connections can be made by XLR or 1/4", and balanced connections are usually preferred as a matter of habit.-Richie