I'm running two Delta 410s with no problems now, at first there was an ACPI conflict, but I reset the CMOS (take the watch battery looking thing out of the motherboard and wait about 30 seconds or so and put it back in) Installed 1 card, booted up, installed, turned off, unplugged, installed card #2, boot, installed, gravy. But I'm the type to go into my BIOS and change everything around, etc. I'm assuming standard default BIOS settings will not conflict with the reading of the two cards.