I had to upgrade my PCI card awhile back to the PCIe when I built my latest PC. I now use the 2408 to interface with my HD24. I also have the 308 and 1224 I use for external FX units. The mixer in the 424 card is awesome if you learn how to use it. I have been pondering on getting another 2408 for my MIDI gear. That would keep me from having to patch things into my current set up.