You'll get more mileage on improving your tone by getting all of the effects OUT of your signal path, particularly if you are going into a tube amp.
Oh, and the absolute best way to make your guitar sound better is to practice making your gutiar sound better. Seriously, practice different pick attacks, change which part of your finger touches the string, or where in relation to the fret it touches, and of course you always want to pay attention to how hard you press. All these things make a difference in what comes out of the speaker. Practice them all.
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