when you record, play on-time so you don't need to quantize... ha-ha.
seriously though, i turn off the PC speaker metronome option, and use the port is have set for my drum machine (asr-x pro).
once you select the range in the track that you want to quantize, setting the note resolution (8th, 8th triplet, etc...) is very important.
also, i don't normally quantize 100%. i go about 75-80%.