Ok, I am going to hurt my brain again. Let's cover total resistance and how this relates to speakers. In these samples we have 2 speakers (SP1 and SP2). Each speaker has a + and - terminal. The resistance for each speaker (8 ohms), will be R1 and R2.
To hook the speakers up in parallel, you take the + power from the amp, and hook that up to the + side of SP1 and SP2. Take the - power from the amp and hook it up to the - side of SP1 and SP2.
To hook the speakers up in series, you take the + power from the amp and hook it up to the + of SP1. Take the - from SP1 and hook it up to + side of SP2. Take the - side of SP2 and hook that to the - side of the power from the amp.
Now to calculate total resistance. If the 2 speakers are hooked up in series, you simply add up the resistance. 8 ohms from SP1 and 8 from SP2 = 16 ohms. To calculate the resistance in parallel you multiply R1*R2 and divide that by R1+R2. Another words, 2 8 ohm speakers in parallel are (8*8) / (8+8) = 4 ohms.
Now the standard way they hook up cabs internally will be 2 sets of 2 speakers each set in parallel, then the 2 sets hooked up in series. Another words, with 8 ohm speakers used, each set will have 4 ohms resistance and add the 2 set together to get 8 ohms for the cabinet.
Now if you have 2 - 8 ohm cabs, you can hook them up in parallel or series. So if you hook them up in parallel, you get 4 ohms total. In series you will get 16.
One last note. You should always keep your loads (speaker cabs) the same. You should not run a 4 ohm cab and hook that up in parallel with an 8 ohm cab. If you do that, the 4 ohm cab will be twice as loud as 8 ohm cab. It will be doing twice the work. Besides the fact that you would come up with 2.67 total resistance and I don't think anyone makes an amp to handle that.
Hope that helps