I got some MoPads for x-mas. They effectively slant my monitors towards my ears, cause they are sitting a bit above head level. As for actual isolation, they only decoupling that they will do that you want to worry about is with the lower frequencies. A 15 khz wave isn't going to resonate through your desk, but a 100hz wave just might. If you have monitors wiht a strong/healthy bass response, you might just want to get some. My nearfields arent very bass heavy (but my bigass room monitors, which are hanging from the cieling, are), so i cant tell you how well the mopads work for that.