Configuring for Reason
The easiest way to configure for Reason has to be the MIDI remote mapping feature of Reason. In the options menu, select edit MIDI remote mapping. This puts you into a mode to assign controls. Click on a control, and an options dialog comes up. Check the learn from MIDI input box, and then fiddle a knob or slider until you see some activity in the MIDI received area of the dialog. Click ok, and you'll notice a channel:controller overlay that tells you which channel and controller now work this control. Clear the edit midi remote mapping (back in the options menu) and enable enable midi remote mapping to instruct Reason to listen for the MIDI maps you set up. That's all there is to it.
You can even set it up so that the same knob affects more than one control. Setting the mod wheel to affect both filters' frequency made for some dramatic sweeps with smooth and easy control. I recorded some of them and then took a look at the curves in Reason's editor. The curves were smooth - at least as smooth as I could make them by changing the mod wheel in real time. Even turning 2 or 3 knobs at the same time exhibited no problems. Note, though, the origin position of the knob and the default origin in Reason - make sure they match, or you'll get a jump when the first control message hits! This is a common issue with any controller, however.