No tweaks but be careful what you add to that OS. Older Roxio/Adaptec products are known to overwrite drivers rendering CD burners useless without doing a registry edit. Also Nero and Kazaa appear to be causing some problems for some users.
Also be careful of DVD playing software. Some DVD movies have players on them that they will install before playing the movie, they will usually ask if the player should be installed. Do not install PC Friendly or InterActual player if you already have DVD playing software. These products are also known to overwrite drivers.
The link Foo gave you should cover all the major OS tweaks you need to do.
Hope this helps
Stray