Exactly the set up in my project studio.
The slickest (but ugliest and least artist friendly) version of this was:
Powerbook 667mhz, 786ram, Lacie firewire HD, 828 and US428.
Excellent automation of Cubase SX1/Reason combination.
Used primarily VI's + heaps of audio (around 28 tracks...bear in mind anything more than 16 audio and I think... turd polishing)
The ability to mix virtually out the box and the sheer compatibility was aces. (Midi went into the US428)
Another good combo, better GUI, better features and...interesting.... summing is DP 4.11 ..same HW system. (Actually my weapon of choice these days). It has it's own sound....
The best version of this was to use the US428 as sound in/out and midi. I ended up not using the 828 at all!! This was for singer songwriter work though and not to be reccomended for bands.
I would have to say that, for bands, 828 is stable and lovely..really all you would need in the prosumer end.
For things you know are going to head for radio and TV. My best combo has been
sameish hardware. (substituted a 1gig imac for the powerbook)
MBox/US428/DP4.11(if a big midi number) or PTLE 6.1.2 if midi is being used subtely and you need nice sounds.
If you're the singersongwriter/like doing most stuff yourself and don't need the inputs of the 828 I would go for this.
The pre's and the converters of 828 and MBox cannot really compare (the MBox is class). Similarly MBox and apogee (more like the studios you work in) etc etc.
Finally the biggest thing I have found to make a difference in sound is mic pre's and convertors to sat nothing of keeping the clocking simple.
Go for sound...all DAW's are NOT the same. All sound interfaces are different. The US428 though, is handy forever!
Jimihey