Also, you can get a lot of milage out of Quadrafuzz.
The other thing is, don't use single-band distortion plugs all by themselves. There is nothing that says you should just put DaTube or Antares Tube on a track, and crank it up to "11" and hope for the best. I routinely sandwitch those between EQs, filters, flangers, phasers, etc. sometimes even using more than one instance. Try using 2-3 of them with mild settings, sandwitched between EQs and other, rather than one instance cranked all the way up. This way you gain an enormous amount of control and soundshaping possibilities.