I use a Laney with a Digitech pedal, but here is the disclaimer: I use it with the clean channel, with a slightly "pinched" EQ. I use a lot of phase and chorus for "shimmering" angellike lead riffs.
When I run the pedal thru the "drive" channel, it always sounds overprocessed for my tastes. But hey, "thats me"!
My opinion is that tube amps have something for everybody....Tube amps, in my opinion, will improve everyones sound, no matter what they play.
BTW, I subscribe to Guitar Techniques (a British publication) and every issue, they put together a schematic re the signal chain of famous guitarists. You would be amazed about how complex and how simple some of your fav guitarists route their signal.
Hope this helps.