I've been running my 44 since 2000 without any problems. It was first installed on a Dell 450mhz under Win98, later upgraded to Win2K. I then moved it to a Dell 2.53ghz with XP Home. No problems. Sound is great! I use it with N-Track. Only "downside" is that the driver updates don't come with an installer. It's just a zip of a bunch of files you have to stick in a folder on your PC, and then when upgrading the drivers (via the Hardware Device Manager) you have to pick the "Select Location of Drivers" and point it to the appropriate folder. Not a huge deal, but can be confusing for the less PC-literate among us (not saying you are!)
Make sure you get the latest drivers off of their website, rather than using the ones that it came with.
Good luck and let us know how it works out!