yeah it'll work fine if you clock one card from the other using the S/PDIF connections. Set one card to internal, go from the S/PDIF out to the IN of the other card and set it to external S/PDIF and you're rocking. I've had 2 1010's, 2 410's and a 2496 running on this system with no problems for ages now, all the Delta cards seem to live comfortably together in a good system with plenty resources.
Alec