If you only have half a guitar it's pretty difficult to find use for a POD or Vamp but if it's a full semi acoustic then, it's fine. Also depends on what you want to do ?
If you want to try to use an acoustic guitar w/ a pick-up through the pod to get a recorded electric guitar sound, you can try it. I did it once just for fun and got some interesting sounds, but it didn't sound like I was playing a true electric. The tone wasn't quite right and obviously you don't get the sustain from an acoustic that you get from an electric. I did get some cool blues sounds. Try and borrow a pod from somebody and just try stuff.
Oh, BTW if you meant that you want to use a semi-hollow or archtop electric with the pod then the answer is yes, of course.
I agree with hongtech that if you only have half of a guitar it will be tough. I guess it depends on which half you have .