What OS is on the mac? You're going to have to go from there backward. You could choose a DAW that will work with Mac's OS, then choose an interface that works with that DAW, the Tascam US1641 works with most DAW's. I know Cubase make a Mac OS DAW. One piece of advice would be get Windows for Mac before you even start to look at other things. My Mac is for online use only, a God send for that, not so much for anything else. Prolly 99% of the software out there is for PC. Start there unless you wanna hit walls at every turn.