The 2000CD is the last VS model made, so it has the USB interface and the harmonizer. THe harmonizer is not very good, btw, unless you keep the harmonies well in the background. My understanding is you would need a dedicated plugin for serious faux harmonizing (I forget which one).
If you get it for less than 1,500.00 USD, then you are getting a reasonable deal. You should also ask whether or not Roland was still offering a VS8F-3 card and UA 1176 LN plugin free of charge. They were doing so up until December, because they were trying to clear stocks, I guess.
Trust me on the fact of the 2000CD's being discontinued. As far as I can tell, so too are the 2400 and the 2480, although they will still be supported by Roland (it's the law, I believe). If I had a chance for a 2000CD at that price, I'd grab it, with the understanding that I have a 30 day no questions asked return policy, in case of a flukey hard drive, or the other assorted gremlins that have showed up with it. As I said, though, my machine has functioned perfectly for over a year, and mine is loaded with 2 VS8F 3 cards and various plugins. I paid 2000 Euros for the machine alone, without the bells and whistles, and I still think I have a great machine.
Best of luck...