That's right the M2524 has unbalanced monitor outs, forgot it's been a while since I used mine. The reason I asked about unplugging each set of monitors is that the earth loop is still there even if you turn the amp/monitors off. Also the loop could be only on 1 set of monitors but the loop is causing the hum to be heard on both.
I am going to suggest lifting the shield at the power amp / active monitor end of the cables, however before doing this just check if they have an earth lift switch.
The earth loop could also be caused by anything else plugged into the desk, thats why you have to unplug everything, plug in 1 set of monitors 1st, then plug each piece of gear until the hum appears. The loop could also be from the layla interface/computer, and don't forget that the mixer will also hum if 2 of the items connected to it have an earth loop. I have spent many hours chasing earth loops over the years and I often find suppressing issues causing them.
Alan.