The inside of a computer is an electronically noisy environment. Which is NOT good for analog audio. You want / need a card with a breakout box if you care about not having a lot of noise in your tracks. Plus with cables being $1+ per foot, being a couple feet closer x8 is a good thing. It's not so much that it injects noise inside the box, but that it's relatively random noise that can't be easily filtered and otherwise draws attention to itself.
Yes and No to using multiple cards simultaneously. Some have means to sync between cards and adjust to match. Most do not. So you might as well be mixing camcorders and reel to reel machines. You'll have to do severe edits in post to make start and stop times match and speed up some of the tracks to run at the same pace. Just a really painful thing to deal with for devices that don't have a means to sync their clocks and auto adjust. And even those that do can be a real unruly beast to wrestle into submission.