Not a lot. They're not real-time information.
It's better to check real time changes under load.
I'm not really certain how to interpret real time HDD IO info, but data read/data written is over time.
If you copied over a 2gb file, you'd see both figures go up by 2gb.
As for the page file, clearly it's not relevant to here/now because you have 4gb ram unused.
The page file would only ever kick in if you ran out of RAM so, again...check under load.
You said something about preferences getting corrupted earlier. Did you mean permissions?
Permissions are generally repaired at the end of any system or major install. Sometimes it's not a bad idea to repair them, although I'm not sure how I'd link that to performance issues.
If you're not on El Capitan you can go to Utilities/Disk Utility, select your system disk and hit 'repair permissions'. No reason not to, I suppose.