I use a strat and tele. Using the bridge pickup(s) is helpful.
I play through the Boss compressor and delay stomp boxes.
The compressor knobs are all pretty much at 12:00. The delay is set long but the effect level is set low, keeping it subtle.
Clean is good but if you can get just a hint of bite, that's nice, too.
Now this is not right or wrong. This is what I do and it works great for me.
A big part of that sound comes from your technique - chicken-pickiing, double stops, pick and finger technique, use of open strings, etc.
.....and so much for my 2 cents.