Not really, well maybe
To answer your questions let me start with what works with TDM. ProToos III, ProTolls IV, D24, Mix and Mix+ are all Digidesign TDM systems. CuBase, Logic, and Digital Performer at one point (I don't know since I haven't kept up with them) all had versions that ran TDM Plug-Ins. Most TDM plugIns are shipped with both the TDM (real time) - and audiosuite (disk based) versions. The only difference between the two is that with the audiosuite, you design the sound you are looking for and then ProTools creates a new soundfile to use in your session. My understanding (and I'm probably wrong) is that the 001 uses the audiosuite Plug-Ins in realtime, RTAS - Real Time AudioSuite. The limitation to this set up is that you can only run as many Plug-Ins and tracks as your computers CPU can deal with. With a TDM system we have a simlar problem, we can only run as many Plug-Ins as our DSP farms can handle. The benifit is that we can ad extra DSP farms, they only cost about $3000.00 - I'm not sure if that is a benifit!