One of the reasons we try to make guitars sound huge on recordings, is that it is needed to give the thing that cannot be had with small stereo speakers, that is there in a live situation. Huge movement of air, ambiance, and balls out volume in a big room. I agree with Greg, in that running a separate cab on the opposite side of the stage will make a big difference, but it really depends on the size of
the venue you are playing, and whom it is you are doing it for. You may be asking to much of a PA to do this for you, if this is a 100 seat/stand venue. You will want to move more air for the front row from stage volume. Much more appropriate for a 700+ room, you will likely have side fills that will help to fill the holes. Get into the 1500 plus, and it will matter less, though, then you may be into a stereo system, and you will want your own FOH tech to tell you what works for your tone. And your groupies to tell you your soundman sucks.
Most important to me, is what makes you, and your band members, feel comfortable on stage. I recommend rehearsing in a live staged format, so that all of you are comfortable with your
backline sound.
If you haven't already, be prepared for either 'freaking the hell out" with a gigantic PA with side fills, because it sounds wicked cool, or getting lost on a big stage, because you cant hear yourself, because the soundman/monitor guy sucks, and your stage rig is inadequate. Either way, the most important, is to be able to perform with the sound that you and your band are comfortable with.
I am a bit deaf, and used to rehearse with 4 18" subs behind me (miked kit) so that I felt comfortable when we played the venues with huge PA. It kinda sucked tho, when we played local bars, cus it was just not the same. Alcohol made that problem less annoying tho. lol
I do not condone heavy drinking to remedy poor situations. Well, I don't anymore....
lol!