Well, there's an idea I work with daily
trying to work with the 12 bar blues form. It comes so naturally, then you've got to make it different from the 10,000 good songs that are also 12 bar blues.
Well, a thing I've been doing,
is take the B section down a minor third.
So, if you were in E,A,E,B7, you go down to:
C#,F#,C#,G#7, and your minor thirds are still the e, a, and b notes.
You can keep the bass playing the same thing, so it plays against the minor thirds of the new chords, rather than the root.
Sorry if this is too obvious, but I like it.