Well, all the guitars are direct into
a Presonus Firestudio Mobile. The Drums are Toontrack Superior 2 which are triggered from my Roland TD-9 vdrum kit. I use some free amp sims for my guitar sounds that are pretty damn good. If you google Poulin
Le456, that is one of them and also Nick Crowe 7170. I use LeCab to load impulses that I bought from redwirez. Vocals are sung into my new SM7B by me. I play drums, bass, and guitar also. There are 2 other guitarists working with me on this project though and if we go live I plan on just singing and that is all.
I do all my stuff in the box. Right now I'm using the FabFilter plugs for most of my Compression, EQ and Limiting. I usually mix my drums first just to get a good sound and then kind of build off of that. I just love playing drums and love drum sounds, so sometimes my drums may be too loud and what not. I send all my different groups: Drums, Bass, Guitars, Vocals to there own faders and limit though just to tame them a tad. Then have my MB Comp at the end, a bit of EQ, and the limiter for volume.
Actually what I do is real basic I guess. It is all about getting used to what each instrument likes as far as compression and EQ and what sound you are looking for. Once you nail that, your all set. I've been home recording since I was about 16 or so, I'm almost 30 now. I started getting deep into the computer recording and mixing properly about 6 years ago. So, I've had some time to develop. You really have to keep at it though, every time I take a break, I feel like I'm coming back in cold but I end up warming up pretty quick. Hope this helps you out a bit.
O also, I double my vocals a lot. I do it myself, same with harmonies, I do them myself and usually avoid the machine. It always sounds more natural that way.