I posted in another thread about mic placement. I have a Randall ISO cab (basically a speaker in a box with a mic stand inside for recording). To make a long story short, I went from 2-3 inches away from the cone to 1/2 inch from the cone and the difference in tone was huge. I went from boxy and muddy to crisp and defined just with a little mic placement.
I tune to a similar note as well (CGCFAD), it sounds good to me now, or at least its a good enough base to mix off of down the line.
I also made sure to start with my presence/bass/mid/treble at 5 and my gain at about 75% and tweaked from there. My recording settings are quite different from my live settings.
Also, in order to get your mic placed as close as possible, you might have to remove your speaker grille. It also seemed to give me a brigher sound when I had my mic facing the slant of the speaker cone.
If this is a side view of your speaker \__/ I had my mic "//" placed like this \//_/. Toward the center of the cone, facing the cone as straight as possible.
In my opinion, the best thing to do would be to experiment. Start with mic placement and do some double tracking. Set your amp EQ to the middle and play something in which you want to hear the definition, record it, move the mic a bit, try again. Then listen to the takes back to back to see which you like better. Once you nail that, start tweaking your amp EQ and repeat the process until you get the tone you like.
At least, that's what I'm doing.