No problem with running the balanced (TRS) outs from your interface back into the mixer...
BUT
(and it's a big but)
How successful you will be will depend on a mix of the software you have in the computer and the capabilities of your mixer.
As you've identified, if you simply feed the line out into the mixer then back into the computer on the main outs, you have created an unusable loop. If the mixer has multiple bus or aux outputs and inputs, you may be able to make things work--but if it's a small cheapie with everything going to a single pair of main outs then you may be stymied.
That's what I do. I drink and I know things.
-Tyrion Lannister (and Bobbsy)
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