Hi Dave,
I don't know about Focusrite gear but with the presonus and motu interfaces I had/have, I could plug them in to the computer and set up what I wanted in their bundled mixer software,
then those settings would 'stick' when I used it as standalone.
For example I plugged in the Firestudio mobile, set it up such that there was direct monitoring from mic input 1 to mains out 1+2, then took it and used it as a standalone preamp in front of an active speaker.
Maybe relevant; Maybe not.