When I switched to Reaper, it was almost like some turning on the lights. It did things the way I expected them to be done. And if I was like, "I wonder if I can do this by doing this", more often than not, I could.
Prior to using a PC, I had an Amiga. There were two programs on the Amiga that I feel have yet to be surpassed in ease of use (for me, not necessarily someone else). The first was Music X, which was a midi program of comparable vintage to Cubase (which, from memory, evolved from C Notater). The second was Deluxe Paint, which suited me way more than Photoshop or Gimp.