I just purchased a MOTU 2408 with the PCI 424 card and am running it on a 3 gighz AMD processor, Gigabyte board, 2gig ram,250gigHD,etc...
I downloaded the latest drivers from Motu and used them for the install. When I try to run Cubase now, it crashes at the point where it is loading VST stuff. I also can not run the ASIO config stuff because it crashes!
I completly removed the Motu PCI 424 board and removed all evidance of it in the registry and then Cubase works fine! Reload the drivers and it stops working again.
oh, I am running Windows XP PRO