Good morning,
Readyboost is good for reading files not writing so It wouldn't help for recording. It will help for plugins if you don't have much ram and you use many of them. If you have an ssd hard drive and have at least 8 gig of ram you definitly don't need that unless you use tons of plugins and work on many tracks. If your thumbdrive and your usb port are not at least usb 2 it will not work. But if your usb port and the usb key are usb 2 or 3 and you do not have a lot of ram and do not have an ssd hard drive then yes you will notice a big difference, especially the second time you load your daw and plugins. It will open faster and be more reactive.
Hope that help!