Thing with lyrics is the presentation (ie "attitude") really matters. Who's singing it and how? One person's voice and delivery could be perfect for an irreverent song, another's could be perfect for a sincere song. but give the irreverent guy a sincere song or vice-versa, it's just not going to sound right.
That being said, I must say if someone's so self-conscious they have to ask strangers if it's ok to sing about something "risky", there's a good chance irreverence ain't their cup o' tea. So I'll be the odd man out and say don't do it, but whatever. It's not like you're risking anything. Good luck.
This ^^^^^^^