The Muther of All Buzzes:

My electronics chops are slightly better than my operatic vocals chops. Forget it. I ain't cutting and soldering nuthin'!

Ok, so transformer box it is then! BUT learning to solder and make/repair simple cables is not hard for someone smart enough to run a computer and sort out an AI and DAW..VERY good skills to acquire.

Dave.
 
One odd thing is that the TotalMix software panel was definitely causing significant buzz if it was open. When closed, it was silent.

Is totalmix routing/direct monitoring software, like Presonus UC or motu Cuemix?

If so, it may be letting you hear any number of inputs live when it's open.
If those inputs have nothing connected, or cables going nowhere or connecting to a turned-off device, that would buzz plenty!
 
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