I used to use Cubase, as I got it free with an Audigy soundcard about 10 years ago, but I always found it very finicky to use. I bought the Adobe CS3 Box set for graphics/video work a few years ago now (2007?) and started using Audition and I found it MUCH easier to use than cubase. The interface is very intuitive as you'd expect from adobe. Earliar this year I got a copy of Cubase 5 with my Zoom R16 and I thought I'd start using that but the same finicky interface issues that I had before were still there and I was not at all happy with it. I recently started using Reaper and I must say I really like it, but I'm still swapping from Reaper to Audition, because I find both have their strengths. I'm learning about mastering at the moment and I just find it easier to work with Auditions effects rack and metering system for mastering than using Reapers. But that said, I've only scratched the surface with reaper. I have WAY more to learn about it.