I usually have my motu2408mk2 "hardwired" to a lexicon lxp5 (outs 7-8 from motu and returns from the LXP to 7-8 inputs on the motu). If I want to use it, I use an auxillary send from the mixer in Cubase sx2 (you can assign the individual sends to interface outputs) to 7-8, then create a stereo return track monitoring inputs 7-8. I usually apply a limiter to the returns too, just in case.
I am soo bad at explaning things in english. Hope it made at least some sense
the passion for destruction is also a creative passion!