I use headphones and a couple different speaker set ups to cross check things...one thing I'm doing to avoid setting up a headphone mix that, once I hear it in the speaker set up I'm using as the focus one, has to be changed, is to identify what the headphones boost in the mix that isn't that way in the speakers...last mix it was the tambourine and bass...figure if I can set up a reference system I'll know what kind of mix to make using them initially...new to pro recording /mixing /mastering though just getting started w/things and like to use the headphones a lot to hear what EQ/compression do (also due to the air conditioner being a noisy one I have to keep turning off to check the speaker mixes.. )