Two kind of noise are affecting electric guitars: 50/60Hz hum and EMI/RFI noise (interference).
If we are talking about hum-free single coil format (Strat, Tele, P90, etc., and not only) and the same time about authentic single coil sounding pickups - there are only Kinman zero-hum pickups. Kinmans are simply perfect authentic sounding, perfect balanced, no hum, and made in the very best quality. I can say - there are Kinman pickups, and all other "noiseless pickups"...
Other talk is about right guitar's shielding-grounding against EMI/RFI noise. The best solution is wood cavities shielding with conductive paint, and plastic parts - pick-guard and cavity covers shielding with aluminium or copper foil. All possible metal parts of guitar must be grounded (including screws, neck plate, truss rod, etc.). Most of all factory made guitars are wrong shielded, and 99.9% of them are wrong grounded, because shield grounds and signal grounds must be separated and connected only at the output jack. Even better is to use TRS stereo jack (with separated grounds - signal ground on the "ring" contact) on guitar, and special (TRS plug - symmetric cable - TS plug) guitar cable - until first input device (connecting grounds together only at TS plug end). Use the ferrite bead (EMI/RFI filter) at the TS (amp/pedal) end of guitar cable for additional protection of you electronic circuits from EMI/RFI noise.