Oh my god, did you actually say Poison in public? I think that's the first time that name has come up on this BBS. Ok...I won't pick on ya too much.
If you want that unnatural late 80's early 90's hair rock sound...then you'll be using effects big time.
Unfortunately your amp is designed to sound pretty damn good, so you'll need to do something about that to get CC's sound. First of all you want quite a bit of treble, half on the mids and maybe half on the bass. Play around with the EQ. That glam rock isn't on the bassy side of distortion, and it doesn't completly cut the mids like some heavy metal.
You'll also have to screw around with your distortion pedal while you're getting that EQ right because they're really intertwined here. You'll want a really smooth and not the least big growly distortion. The distortion on your amp won't cut it because it's good tube driven distortion...the stuff that rockers during the Poison era were not into. Just about any distortion pedal that existed during that time will give you the sound you're looking for. I know I can get it out of my old Boss multieffects pedal no problem.
Once you get a basic sound down then you'll get the smoothness with compression. Compress the piss out of your signal until it sounds cheesy...err good. Use some sustain if your compressor has some sort of sustain feature.
80's rockers were not into reverb too much because it's too realistic. Go the delay route. Use a short delay with fast decay to beef up the sound without being obvious.
Finally, effects effects effects. Every single time you go to a clean channel you'll want to use a shitload of chorus to mask any sort of flaws in your playing. Experiment also with stereo flange on your distorted signal. Those were the two most overused effects during that time period.
Your guitar doesn't matter too much. Hell, CC played a BC Rich if I remember correctly. Basically the speed of the guitar is more important than the sweetness or weight. Use
ultralight strings. Use a HUMBUCKER. Single coil pickups will NOT sound right.
Or, you can trade in all of your great equipment for a 1990 model Crate stack and digtal effects pedal and just plug your guitar in. That'll pretty much do it for ya.
Slackmaster 2000